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June 2021 Volume 7 Issue 2

“A Study of the Clinico-Epidemiological Profile of Covid-19 Patients Admitted in a Tertiary Care Hospital in India”

Vaishali Singh, R. Sujatha, Deepak Sameer, Arunagiri D

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Introduction- COVID-19, or more popularly known as Novel Corona Virus, is associated with the respiratory disorder in humans which has been declared as a global epidemic and pandemic in the first quarter of the year 2020 by the World Health Organization

Aim: To Study the Clinico-epidemiological Profile of COVID-19 Patients Admitted in a Tertiary Care Hospital in Kanpur, UP, India.

Material and Methods: It is a retrospective study that investigated170 Real Time-Polymerase Chain Reaction (RT-PCR) confirmed COVID-19 patients from June2020 to August 2020.

Results: Out of 170 laboratories confirmed adult COVID-19 patients Men were 116 (68.23%) and women were 54 (31.76%). There were 48 (28.23%) symptomatic and 122 (71.76%) asymptomatic patients. The mean CT value in symptomatic patient was 26.05 and in asymptomatic patient were 25.30. Maximum no. of patients belong to the age group of 61-70 yrs. Most common symptom was fever followed by cough and breathlessness.

Conclusion: Among the hospitalized patients in the tertiary care hospital, fever was the most common symptom followed by cough and breathlessness and the maximum no. positive cases were from elderly people who may be attributed to their weak immunity or any co morbidity.

“Prevalence of Carbapenem Resistant Enterobacteriaceae in A Tertiary Care Hospital”

R. Sujatha, Deepak Sameer, Arunagiri D

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Objective: The emergence of Carbapenem Resistant Enterobacteriaceae (CRE) in recent times has
become a serious threat to public health due to the high mortality, potential dissemination rates and
limited treatment options associated with these organisms. Thus, the present study was conducted
in our tertiary care hospital to retrospectively analyze the prevalence of CRE in the hospital.
Methods: The study was carried out in the microbiology department of the tertiary care hospital
over a period of 24 months. The samples tested were clinical samples from hospitalized and OutPatient Department (OPD) patients sent to the department for microbiological testing. CRE isolates
were identified using the standard protocol.
Results: A CRE prevalence rate of 16.28% was obtained from the study, from which the majority
of the isolates were detected in urine samples (27.90%). Although most of the CRE isolates were
detected in patient samples from the ICU (46.51%), Klebsiella pneumoniae is the most common
isolate (53.48%).
Conclusion: Thus, the study shows a significant rate of carbapenem resistance among
Enterobacteriaceae isolated from hospitalized patients. This emphasizes the urgent need for CRE
control at the hospital, by following proper infection control measures, antimicrobial stewardship,
and to rationalize the use of antibiotics

“Clinicomycological Study of Dermatomycosis in A Tertiary Care Hospital”

R. Sujatha, Deepak Sameer, Arunagiri D

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Background: Dermatophytosis refers to superficial fungal infection of keratinized tissues caused
by dermatophytes. Dermatophytes colonize only the cornfield layer of epidermis or suprafollicular
portions of hair and do not penetrate into deeper anatomical sites. Although Dermatophytosis is not
bilitating or life threatening, it can be persistent, troublesome and are often confused with other skin
disorders. So, laboratory investigations are essential for correct diagnosis, management and to
minimize cost.
Objectives of Study: To isolate & speciate the dermatophytes & to analyze clinico-mycological
profile of Dermatophytosis at a teritiary care centre.
Material and Methods: Samples like skin scrapings, nail clippings, hair & hair stub were
processed for 50 clinically suspected Dermatophytosis cases. All the samples were subjected for
KOH mount & culture on to SDA.
Results: Majority of the patients were male 35(70%) compared to female 15(30%). Most
commonly affected age group 21-30 years (36%). Infection was most commonly seen in
students(32%) and agriculture workers(16%).Tinea corporis was the predominant type comprising
18(36%), followed by Tinea cruris 16(32%), Tinea capitis 6(12%),T.pedis (10%).T.corporis
showed growth of T.mentagraphytes (22.22%),T.rubrum(16.66%),T.verucossum (5.5%) and
M.manum, T.cruris showed growth of T.rubrum(31.5%),T.mentagraphytes (12.5%),
T.verucossum(6.5%) and E.flocossum(6.5%). T.capitis showed growth of T.mentagraphytes 4
(66.66%). T.pedis showed growth of T.rubrum(20%) T.mentagraphytes(20%).
Conclusion: Dermatophyte infections are very common in our setup,where hot and humid climate
along with the poor hygienic conditions favor the growth of these fungi. There is varying
difference in isolation of different species across the different parts of India. The predominant
species was the Trichophyton rubrum followed by Trichophyton mentagrophytes,

“Microbiological Profile of Blood Culture Isolates of Septicemia in A Tertiary Care Center In Kanpur”

R. Sujatha, Deepak Sameer, Arunagiri D.

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Introduction: Bloodstream infections (BSIs) have serious consequences such as shock,
disseminated intravascular coagulation, multiple organ failure, and even death. Increased mortality
due to sepsis and bacteremia impacts health-care activities severely early diagnosis plays a crucial
role in managing BSI, and hence, prompt detection of such infections is a critical function of clinical
microbiology laboratories.
Aim: The aim is to study the prevalence of microorganism causing bloodstream infections leading to
septicemia in a tertiary care center.
Material and Methods: A total of 1030 blood samples were received in the Microbiology
Department of a teritiary care Hospital from November 2017, to october 2018. The samples were
processed as per standard techniques. Identification and antimicrobial susceptibility testing were
done by and Kirby–Bauer disc diffusion method as per the Clinical and Laboratory Standards
Institute guidelines.
Results: Of total 1030 blood culture samples received in laboratory, 68 (6.6%) were culture positive.
The Gram-negative bacteria 35 (51.4%) were isolated in majority followed by Gram-positive
bacteria 23 (33.82%) and Candida spp. 10 (14.70%). Klebsiella pneumoniae (71.4%%) was most
common isolate among the Enterobacteriaceae. Whereas among the non-fermenting Gram-negative
bacteria isolates, Pseudomonas spp. (80%) was most common. Gram-negative bacteria were resistant
to commonly used antibiotics. 60–80% resistance was observed against carbapenems. Least
resistance was seen to last resort antibiotics, i.e., tigecycline and colistin. Among the GPC isolates
Staphylococcus aureus were 65.21% and Enterococcus spp was34.78%. Gram-positive bacteria
were resistant to commonly used antibiotics.GPC isolates were 100% sensitive to Vancomycin,
Linezolid and Teicoplanin .Candida albicans was 60%,Candida krusei (20%), and Candida
glabrata (20%).
Conclusion: The increased isolation of multidrug-resistant Gram-negative bacteria is distressing,
and further studies are advocated to help in the formulation of treatment and preventive strategies so
as to curb such emergence.
Key words: Bloodstream infection, gram-negative bacteremia, sepsis.

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