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September 2020 Volume 6 Issue 3

“Microbiological Study of Onychomycosis at A Tertiary Care Hospital Kanpur”

R. Sujatha, Deepak Sameer, Arunagiri D

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Background: Onychomycosis is a common fungal infection of nail poses to be an important public health problem. Fungal nail infection accounts for almost 50% of all nail diseases it may be caused by dermatophytes, non-dermatophytic moulds or yeasts involving nail bed, nail plate or matrix of nail Onychomycosis. Further, management of fungal infections of nails usually requires a prolonged course with a tendency for relapse.

Aim: The present study was undertaken to isolate and identify the etiological agents of onychomycosis.

Material & Methods: A cross-sectional study was done over a 1 year period, in clinically suspected cases of onychomycosis, a thorough clinical evaluation was performed, followed by microscopically examining the infected nail specimen under 40% potassium hydroxide, which was succeeded by cultivating the organisms on fungal culture media and identifying the pathogen both by closely studying colony morphology in culture and also microscopically utilizing lacto phenol cotton blue staining.

Results: Females (60%) were more commonly affected than males (40%). The most common age group affected was 30-40 years (30%). Females showed more finger nail involvement (60%) and males toe nail involvement (40%)... Onychomycosis was most commonly seen in house wives (50%), followed by farmers (30%),   Out of the 100 patients in our study, 10 demonstrated onychomycosis positive fungal growth on culture. Non dermatophyte moulds (NDM) (80%) were the most common fungal isolates followed by Candida species (10%) and dermatophytes (10%).

Conclusion: Unlike most studies, NDM constituted the major pathogen among our patients. Onychomycosis can affect a wide age group involving both males and females though fingernail involvement was mostly found in females, especially housewives doing greater household work. Despite low fungal isolation rate, fungal culture and antifungal susceptibility testing is utmost importance to know the major fungal a etiology and drug resistance pattern in the locality for better management of onychomycosis cases

“A Study of Hematological and Biochemical Analysis of Covid-19 Patients Admitted In A Tertiary Care Hospital in India”

Vaishali Singh, Deepak Sameer, R. Sujatha, Arunagiri D

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Introduction: Covid 19 is caused by SARS CoV 2. The characteristics of lab findings are of great significance for clinical diagnosis and treatment.

Aim: To study the hematological and biochemical analysis of Covid 19 patients admitted in a tertiary care center in Kanpur.

Material and Methods: It is a retrospective study that investigated170 Real Time-Polymerase Chain Reaction (RT-PCR) confirmed COVID-19 patients from May 2020 to August 2020.

Results: A total of 170 laboratory confirmed adult COVID-19 patients data admitted were included. Hematological findings showed Thrombocytopenia was seen in 5.8% patients, decreased hematocrit in 32.94% patients, neutrophilia in 35.29% patients, lymphocytopenia in 30.58%, monocytopenia in 7.05% patients, increased RBC counts  was seen in 70.58% patients , Leukocytosis was seen in 32.94% patients, and leucopenia was seen in 4.7% patients. Biochemical Findings in Covid 19 patients include increased Blood urea (9.41%) and decreased sodium level (14.11%). Fluctuating levels were seen in Uric acid concentration, SGOT and SGPT.

Conclusion: Particular attention should be given to the hematological and biochemical investigation of patients with COVID-19, particularly in older patients with severe symptoms. Increased attention to these investigations will help to better protect and manage COVID-19 patients and to decrease mortality.

“Study of D-Dimer and CRP Level in Covid-19 Patients Admitted in A Tertiary Care Hospital in India”

Vaishali Singh, Deepak Sameer, R. Sujatha , Arunagiri D

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Introduction: Currently, the novel corona virus disease 2019 (COVID-19) has become one of the deadliest pandemics that has ravaged the world and carries a high mortality rate.

Aim: To study D-dimer and CRP level in Covid-19 patients admitted in a tertiary care center in Kanpur.

Material and Methods: It is a retrospective study that investigated 25 Real Time-Polymerase Chain Reaction (RT-PCR) confirmed COVID-19 patients from June 2020 to August 2020.

Results:  A total of 25 lab confirmed adult Covid-19 patient’s data admitted were included. The maximum number of patients belonged to the age group of 51-60 years in which male were 88.88% and females were 11. In case of CRP 28% were mildly infected, 36% were moderately infected, 20% were severely infected. In case of D-dimer 28% were mildly infected and 40% were severely infected.

Conclusion: CRP value greater than 100 mg/dl and D-dimer level higher than 500 ng/ml might predict the severity of disease so its values should be taken into consideration while treatment.

“Microbiological Profile of Blood Stream Isolates in Urosepsis from A Tertiary Care Hospital”

R. Sujatha, Deepak Sameer, Arunagiri D.

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Urosepsis implies to a clinically evident severe infection of the urinary tract associated with features of systemic inflammatory response syndrome or bacteremia. This study was conducted to determine the bacteriological profile and antimicrobial susceptibility pattern of the organisms associated with urosepsis. A descriptive study was carried out after obtaining approval from Institute Ethics Committee. Demographic details, duration of hospital stay, underlying risk factors, bacteriological profile and antimicrobial susceptibility pattern of the isolates, were recorded from  10 patients confirmed to have urosepsis.. Overall incidence of urosepsis was 3.57% in patients admitted to the hospital during the study period. Type 2 diabetes mellitus was the major risk factor (50%), with underlying renal conditions of chronic kidney disease. Escherichia coli were the predominant isolate (75%).  Early recognition of symptoms followed by accurate diagnosis and early goal directed therapy is essential to decrease morbidity and mortality from urosepsis.

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